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Phthalan, 98% - CAS 496-14-0 - Formula C8H8O


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A10217
Phthalan, 98%

CAS: 496-14-0 MDL: MFCD00005932  EINECS: 207-815-2
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Alternate Name: 1,3-Dihydrobenzo[c]furan
1,3-Dihydroisobenzofuran

 

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Chemical Properties

Formula: C8H8O  Flash point: 63°(145°F)
Formula weight: 120.15  Density: 1.094
Boiling point: 192° Refractive Index: 1.5460

Literature References

For use in synthesis of nine-membered cyclic dione ethers, see: Synlett, 909 (1993).

Treatment of phthalan with excess Li metal in the presence of 4,4'-Di-tert-butyl­biphenyl­, B21470, results in opening of the furan ring. Sequential introduction of two different electrophiles can be effected in the resulting bis-benzylic species, consequently phthalan can be regarded as an o-xylene dianion synthon. This approach provides a convenient access to diols and hydroxy acids which can be readily dehydrated to benzo-fused 6- or 7-membered cyclic ethers or lactones: Tetrahedron, 51, 3351 (1995); see also: J. Org. Chem., 61, 4913 (1996); Tetrahedron Lett., 39, 7759 (1998).


Other References

Beilstein: 111932
Harmonized Tariff Code:   2932.99

GHS Hazard and Precautionary Statements

Hazard Statements : H227

Combustible liquid.

Precautionary Statements : P210-P280-P370+P378A-P403+P235-P501A

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. In case of fire: Use for extinction: CO2, powder or water spray. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Risk & Safety

TSCA: No