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Phenyl phosphorodichloridate, 97% - CAS 770-12-7 - Formula C6H5Cl2O2P

A10479 770-12-7 Phenyl phosphorodichloridate, 97% Phenyl dichlorophosphate Alfa Aesar

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A10479
Phenyl phosphorodichloridate, 97%

CAS: 770-12-7 MDL: MFCD00002067  EINECS: 212-220-6
UN#:UN2922Hazard Class:8Packing Group:II
Alternate Name: Phenyl dichlorophosphate

 

Pricing and Availability

Size ($) Price Your Price Quantity Options Availability
25g 23.40 Check Availability Add to Favorites Enter qty and click checkbox
100g 56.80 Check Availability Add to Favorites Enter qty and click checkbox
500g 249.00 Check Availability Add to Favorites Enter qty and click checkbox


Chemical Properties

Formula: C6H5Cl2O2P  Flash point: 112°(233°F)
Formula weight: 210.98  Density: 1.415
Melting point: -1° Refractive Index: 1.5230
Boiling point: 241-243° Sensitivity: Moisture Sensitive

Literature References

Reagent for the preparation of phosphate diesters. The phenyl group is removable by hydrogenolysis: J. Am. Chem. Soc., 75, 4510 (1953).

Coupling reagent, e.g. in pyridine for the preparation of derivatives of sulfinic acids with alcohols, amines, thiols etc.: Synthesis, 937 (1980). Similarly, carboxylic acids in pyridine can be coupled with thiols to give thiocarboxylic acid S-esters: Can. J. Chem., 58, 2645 (1980), and with sodium azide in the presence of a phase-transfer catalyst to give acyl azides: Synth. Commun., 13, 289 (1983).

Reacts with the Li enolates of ß-diketones, in the presence of LiCl, to give ß-chloro-ɑß-enones: Can. J. Chem., 64, 520 (1986).

In combination with NaI, cleaves dialkyl ethers to iodides in high yield: Synth. Commun., 18, 119 (1988), and 1,3-dithianes and other dithioacetals to carbonyl groups: Tetrahedron Lett., 29, 5471 (1988).

In combination with Dimethyl­ sulfoxide, A13280, effects selective oxidation of alcohols to aldehydes or ketones with less ɑ-chlorination than the more usual Swern (Oxalyl­ chloride, A18012) system: J. Org. Chem., 52, 5621 (1987). Similarly, benzylamines have been converted to benzaldehydes: Synth. Commun., 19, 3407 (1989).

For a brief feature on uses of the reagent in synthesis, see: Synlett, 1651 (2004).


Applications

Reagent for preparation of phosphate diesters

Other References

Beilstein: 511863
UN#: UN2922
Harmonized Tariff Code: 2920.90

GHS Hazard and Precautionary Statements

Hazard Statements : H301-H310-H314-H318

Toxic if swallowed. Fatal in contact with skin. Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements : P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501A

Do not breathe dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

CorrosiveToxic

Risk & Safety

Risk Phrases: 22-27-34
Harmful if swallowed. Very toxic in contact with skin. Causes burns.
Safety Phrases: 26-28-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Very Toxic
TSCA: Yes
RTECS: TD4393000