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A10807 25952-53-8 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 98+% EDAC EDCI Alfa Aesar

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A10807
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 98+%

CAS: 25952-53-8 MDL: MFCD00012503  EINECS: 247-361-2
Not regulated for shipping
Alternate Name: EDAC
EDCI

 

Pricing and Availability

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25g 187.00 Check Availability Add to Favorites Enter qty and click checkbox


Chemical Properties

Formula: C8H17N3•HCl  Melting point: ca 113°
Formula weight: 191.70  Sensitivity: Moisture Sensitive

Literature References

'Water-soluble carbodiimide', widely used for peptide coupling (see Appendix 6), with the major advantage that excess reagent and the urea by-product can be easily removed by washing with dilute acid or water: J. Org. Chem., 26, 2525 (1961); J. Am. Chem. Soc., 87, 2492 (1965). For discussion of the mechanism of peptide coupling with this reagent, see: J. Am. Chem. Soc., 103, 7090 (1981).

Often used in conjunction with an additive such as HOBt (1-hydroxybenzotriazole hydrate) to suppress racemization; see, for example: Bull. Chem. Soc. Jpn., 55, 2165 (1982). A two-phase solvent system (dichloromethane-water or isopropyl acetate-water) has been found to give superior results in this type of peptide coupling: J. Org. Chem., 60, 3569 (1995). In a comparative study, submolar quantities HOBt in DMF-water gave good results: Chem. Lett., 1 (1997).

For use in the synthesis of cyclic derivatives of 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates, see: Angew. Chem. Int. Ed., 33, 1394 (1994).

Promotes various other N-acylation reactions such as the formation of N-acylsulfonamides from primary sulfonamides and N-protected amino acids in the presence of DMAP: Synlett, 1141 (1995).

For use in the acylation of phosphoranes, see (Cyanomethyl)­triphenyl­phosphonium chloride, A13096.


Other References

Beilstein: 5764110
Harmonized Tariff Code: 2925.19

GHS Hazard and Precautionary Statements

Hazard Statements : H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements : P261-P280-P305+P351+P338-P304+P340-P405-P501A

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Harmful or Irritant

Risk & Safety

Risk Phrases: 36/37/38
Irritating to eyes, respiratory system and skin.
Safety Phrases: 26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable gloves. This material and/or its container must be disposed of as hazardous waste.
Irritant
TSCA: Yes
RTECS: FF2200000