1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 98+%
|Not regulated for shipping|
Pricing and Availability
|Size||($) Price||Your Price||Quantity||Options||Availability|
|1g||21.50||Enter qty and click checkbox|
|5g||52.70||Enter qty and click checkbox|
|25g||187.00||Enter qty and click checkbox|
|Formula:||C8H17N3•HCl||Melting point:||ca 113°|
|Formula weight:||191.70||Sensitivity:||Moisture Sensitive|
'Water-soluble carbodiimide', widely used for peptide coupling (see Appendix 6), with the major advantage that excess reagent and the urea by-product can be easily removed by washing with dilute acid or water: J. Org. Chem., 26, 2525 (1961); J. Am. Chem. Soc., 87, 2492 (1965). For discussion of the mechanism of peptide coupling with this reagent, see: J. Am. Chem. Soc., 103, 7090 (1981).
Often used in conjunction with an additive such as HOBt (1-hydroxybenzotriazole hydrate) to suppress racemization; see, for example: Bull. Chem. Soc. Jpn., 55, 2165 (1982). A two-phase solvent system (dichloromethane-water or isopropyl acetate-water) has been found to give superior results in this type of peptide coupling: J. Org. Chem., 60, 3569 (1995). In a comparative study, submolar quantities HOBt in DMF-water gave good results: Chem. Lett., 1 (1997).
For use in the synthesis of cyclic derivatives of 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates, see: Angew. Chem. Int. Ed., 33, 1394 (1994).
Promotes various other N-acylation reactions such as the formation of N-acylsulfonamides from primary sulfonamides and N-protected amino acids in the presence of DMAP: Synlett, 1141 (1995).
For use in the acylation of phosphoranes, see (Cyanomethyl)triphenylphosphonium chloride, A13096.
|Harmonized Tariff Code:||2925.19|
GHS Hazard and Precautionary Statements
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
Risk & Safety
|Irritating to eyes, respiratory system and skin.|
|In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable gloves. This material and/or its container must be disposed of as hazardous waste.|