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Phenylhydrazine, 97% - CAS 100-63-0 - Formula C6H8N2


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A11246
Phenylhydrazine, 97%

CAS: 100-63-0 MDL: MFCD00007573  EINECS: 202-873-5
UN#:UN2572Hazard Class:6.1Packing Group:II

 

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Chemical Properties

Formula: C6H8N2  Density: 1.099
Formula weight: 108.14  Refractive Index: 1.6065
Melting point: 18-20° Sensitivity: Air & Light Sensitive
Boiling point: 238-241° Solubility: Soluble in dilute acids
Flash point: 88°(190°F) 

Literature References

Derivatizing agent for the conversion of carbonyl compounds to their phenylhydrazones best known as intermediates in the Fischer indole synthesis, by cyclization under acidic conditions with loss of ammonia. The classical reagent is anhydrous ZnCl2: Org. Synth. Coll., 3, 725 (1976). For reviews, see: Chem. Rev., 63, 373 (1963); 69, 227 (1969); Tetrahedron, 36, 161 (1980); Org. Prep. Proced. Int., 25, 609 (1993). Milder cyclization conditions are sometimes effective, e.g.: dilute H2SO4: J. Org. Chem., 59, 3738 (1994); PCl3: J. Chem. Soc., Chem. Commun., 563 (1981); Tetrahedron, 41, 4615 (1985). Cyclohexanone phenylhydrazone gives tetrahydrocarbazole on heating in acetic acid: Org. Synth. Coll., 4, 884 (1963).

Methods used for the cleavage of phenylhydrazones include exchange by refluxing with acetone: J. Org. Chem., 40, 3302 (1975), or oxidative cleavage by Fe(NO3)3 on a clay support: Synthesis, 439 (1985).


Other References

Merck: 14,7293
Beilstein: 606080
UN#: UN2572
Harmonized Tariff Code:   2928.00

GHS Hazard and Precautionary Statements

Hazard Statements : H301-H311-H331-H315-H319-H317-H350-H372-H341-H400-H227

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause cancer. Causes damage to organs through prolonged or repeated exposure. Suspected of causing genetic defects. Very toxic to aquatic life. Combustible liquid.

Precautionary Statements : P210-P301+P310-P305+P351+P338-P361-P405-P501A

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

ToxicHealth HazardDangerous for the environment

Risk & Safety

Risk Phrases: 45-23/24/25-36/38-43-48/23/24/25-68-50
May cause cancer. Toxic by inhalation, in contact with skin and if swallowed. Irritating to eyes and skin. May cause sensitisation by skin contact. Toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. Possible risk of irreversible effects Very toxic to aquatic organisms.
Safety Phrases: 53-45-61
Avoid exposure - obtain special instructions before use. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid release to the environment. Refer to special instructions/Safety data sheets
Toxic Dangerous for the environment
TSCA: Yes
RTECS: MV8925000