|UN#:||UN2572||Hazard Class:||6.1||Packing Group:||II
||C6H8N2 || ||Density:
||108.14 || ||Refractive Index:
||Air & Light Sensitive |
||Soluble in dilute acids|
Derivatizing agent for the conversion of carbonyl compounds to their phenylhydrazones best known as intermediates in the Fischer indole synthesis, by cyclization under acidic conditions with loss of ammonia. The classical reagent is anhydrous ZnCl2: Org. Synth. Coll., 3, 725 (1976). For reviews, see: Chem. Rev., 63, 373 (1963); 69, 227 (1969); Tetrahedron, 36, 161 (1980); Org. Prep. Proced. Int., 25, 609 (1993). Milder cyclization conditions are sometimes effective, e.g.: dilute H2SO4: J. Org. Chem., 59, 3738 (1994); PCl3: J. Chem. Soc., Chem. Commun., 563 (1981); Tetrahedron, 41, 4615 (1985). Cyclohexanone phenylhydrazone gives tetrahydrocarbazole on heating in acetic acid: Org. Synth. Coll., 4, 884 (1963).
Methods used for the cleavage of phenylhydrazones include exchange by refluxing with acetone: J. Org. Chem., 40, 3302 (1975), or oxidative cleavage by Fe(NO3)3 on a clay support: Synthesis, 439 (1985).
|Harmonized Tariff Code:
GHS Hazard and Precautionary Statements
Hazard Statements : H301-H311-H331-H315-H319-H317-H350-H372-H341-H400-H227
Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause cancer. Causes damage to organs through prolonged or repeated exposure. Suspected of causing genetic defects. Very toxic to aquatic life. Combustible liquid.
Precautionary Statements : P210-P301+P310-P305+P351+P338-P361-P405-P501A
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
Risk & Safety
|May cause cancer. Toxic by inhalation, in contact with skin and if swallowed. Irritating to eyes and skin. May cause sensitisation by skin contact. Toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. Possible risk of irreversible effects Very toxic to aquatic organisms.
|Avoid exposure - obtain special instructions before use. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid release to the environment. Refer to special instructions/Safety data sheets