Phenylhydrazine, 97%

CAS Number 100-63-0

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Phenylhydrazine, 97%

MDL: MFCD00007573
EINECS: 202-873-5

Chemical Properties

Formula: C6H8N2  Density: 1.099
Formula weight: 108.14  Refractive Index: 1.6065
Melting point: 18-20° Sensitivity: Air & Light Sensitive
Boiling point: 238-241° Solubility: Soluble in dilute acids
Flash point: 88°(190°F) 

Literature References

Derivatizing agent for the conversion of carbonyl compounds to their phenylhydrazones best known as intermediates in the Fischer indole synthesis, by cyclization under acidic conditions with loss of ammonia. The classical reagent is anhydrous ZnCl2: Org. Synth. Coll., 3, 725 (1976). For reviews, see: Chem. Rev., 63, 373 (1963); 69, 227 (1969); Tetrahedron, 36, 161 (1980); Org. Prep. Proced. Int., 25, 609 (1993). Milder cyclization conditions are sometimes effective, e.g.: dilute H2SO4: J. Org. Chem., 59, 3738 (1994); PCl3: J. Chem. Soc., Chem. Commun., 563 (1981); Tetrahedron, 41, 4615 (1985). Cyclohexanone phenylhydrazone gives tetrahydrocarbazole on heating in acetic acid: Org. Synth. Coll., 4, 884 (1963).

Methods used for the cleavage of phenylhydrazones include exchange by refluxing with acetone: J. Org. Chem., 40, 3302 (1975), or oxidative cleavage by Fe(NO3)3 on a clay support: Synthesis, 439 (1985).

GHS Hazard and Precautionary Statements

Hazard Statements : H301-H311-H331-H315-H319-H317-H350-H372-H341-H400-H227

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause cancer. Causes damage to organs through prolonged or repeated exposure. Suspected of causing genetic defects. Very toxic to aquatic life. Combustible liquid.

Precautionary Statements : P210-P301+P310-P305+P351+P338-P361-P405-P501A

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

ToxicHealth HazardDangerous for the environment

Other References

Merck: 14,7293
Beilstein: 606080
UN#: UN2572
Hazard Class: 6.1
Packing Group: II
Harmonized Tariff Code: 2928.00
RTECS: MV8925000
Phenylhydrazine, 97% - CAS 100-63-0 - Formula C6H8N2


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