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Anisole, 99% - CAS 100-66-3 - Formula C7H8O

A12997 100-66-3 Anisole, 99% Methoxybenzene Methyl phenyl ether Alfa Aesar


Certificate of Analysis

Anisole, 99%

CAS: 100-66-3 MDL: MFCD00008354  EINECS: 202-876-1
UN#:UN2222Hazard Class:3Packing Group:III
Alternate Name: Methoxybenzene
Methyl phenyl ether


Pricing and Availability

Size ($) Price Your Price Quantity Options Availability
500g 35.60 Check Availability Add to Favorites Enter qty and click checkbox
2500g 115.00 Check Availability Add to Favorites Enter qty and click checkbox

Chemical Properties

Formula: C7H8O  Flash point: 43°(109°F)
Formula weight: 108.14  Density: 0.994
Melting point: -37° Refractive Index: 1.5170
Boiling point: 153-154° 

Literature References

The rate of ortho-lithiation of anisole is accelerated dramatically in the presence of TMEDA, effective also in sub-stoichiometric amounts: Tetrahedron Lett., 35, 385 (1994). For discussion of the mechanism of ortho-lithiation, see: J. Org. Chem., 62, 3024 (1997). Although direct dilithiation with n-BuLi/TMEDA was unsuccessful, a sequence involving monolithiation, silylation and further lithiation at the 6-position gave the 2,6-disilyl derivative in 72% yield: J. Org. Chem., 49, 4657 (1984).

Widely used as a carbocation scavenger in the deblocking of, e.g. N-Boc or N-Cbz (Z) peptides with acidic reagents. Addition of anisole removes t-butyl or benzyl cations from the reaction mixture; see, e.g.: J. Chem. Soc., Chem. Commun., 922 (1976); Chem. Pharm. Bull., 25, 2929 (1977); Chem. Ber., 101, 3649 (1968).

Other References

Merck: 14,669
Beilstein: 506892
UN#: UN2222
Harmonized Tariff Code: 2909.30

GHS Hazard and Precautionary Statements

Hazard Statements : H331-H315-H319-H335-H226-H303

Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Flammable liquid and vapour. May be harmful if swallowed.

Precautionary Statements : P210-P261-P303+P361+P353-P305+P351+P338-P405-P501A

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.


Risk & Safety

Risk Phrases: 10-20-36/37/38
Flammable. Harmful by inhalation. Irritating to eyes, respiratory system and skin.
Safety Phrases: 9-23-26-36/37-60
Keep container in a well ventilated place. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves. This material and/or its container must be disposed of as hazardous waste.
RTECS: BZ8050000