|UN#:||UN2924||Hazard Class:||3||Packing Group:||II
||C4H15NSi2 || ||Density:
||133.34 || ||Refractive Index:
||Moisture Sensitive |
Reagent for the preparation (see Appendix 4) of dimethylsilyl (DMS) derivatives, compare Hexamethyldisilazane, A15139. With allylic and homoallylic alcohols, the products can undergo Pt- or Rh-catalyzed intramolecular hydrosilylation, providing a regioselective route to 1,3-diols: J. Am. Chem. Soc., 108, 6090 (1986). For an example of this reaction, see Chlorodimethylsilane, A13113.
The potassium derivative, formed by reaction with KH in THF, reacts with alkyl halides to give, after hydrolysis, high yields of primary amines, thus providing a convenient alternative to the classical Gabriel method. Other silazanes, including hexamethyldisilazane, give lower yields: Synthesis, 150 (1995):
|Harmonized Tariff Code:
GHS Hazard and Precautionary Statements
Hazard Statements : H225-H314-H318
Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements : P210-P280-P303+P361+P353-P305+P351+P338-P310
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
Risk & Safety
|Flammable. Causes burns.
|Keep container in a well ventilated place. Keep away from sources of ignition - No Smoking. When using do not eat or drink. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Take precautionary measures against static discharges. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). This material and/or its container must be disposed of as hazardous waste.