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A14451 354-38-1 2,2,2-Trifluoroacetamide, 97% Alfa Aesar


Certificate of Analysis

2,2,2-Trifluoroacetamide, 97%

CAS: 354-38-1 MDL: MFCD00008008  EINECS: 206-559-9
Not regulated for shipping


Pricing and Availability

Size ($) Price Your Price Quantity Options Availability
25g 36.80 Check Availability Add to Favorites Enter qty and click checkbox
100g 101.00 Check Availability Add to Favorites Enter qty and click checkbox
500g 304.00 Check Availability Add to Favorites Enter qty and click checkbox

Chemical Properties

Formula: CF3CONH2  Melting point: 70-75°
Formula weight: 113.04  Boiling point: 162-164°

Literature References

Has been used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group: Synthesis, 941 (1984). For improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups, see: Synth. Commun., 18, 791 (1988). The method has been further extended by the use of ɑ-bromo esters to provide a high yielding route to ɑ-amino acids: J. Org. Chem., 56, 420 (1991):

Other References

Beilstein: 1753625
Harmonized Tariff Code: 2924.19

GHS Hazard and Precautionary Statements

Hazard Statements : H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements : P261-P280-P305+P351+P338-P304+P340-P405-P501A

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Harmful or Irritant

Risk & Safety

Risk Phrases: 36/37/38
Irritating to eyes, respiratory system and skin.
Safety Phrases: 26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable gloves.