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4-Nitrobenzyl bromide, 97+% - CAS 100-11-8 - Formula C7H6BrNO2

A15236 100-11-8 4-Nitrobenzyl bromide, 97+% alpha-Bromo-4-nitrotoluene Alfa Aesar


Certificate of Analysis

4-Nitrobenzyl bromide, 97+%

CAS: 100-11-8 MDL: MFCD00007373  EINECS: 202-820-6
UN#:UN3261Hazard Class:8Packing Group:II
Alternate Name: alpha-Bromo-4-nitrotoluene


Pricing and Availability

Size ($) Price Your Price Quantity Options Availability
25g 36.40 Check Availability Add to Favorites Enter qty and click checkbox
100g 109.00 Check Availability Add to Favorites Enter qty and click checkbox
500g 440.00 Check Availability Add to Favorites Enter qty and click checkbox

Chemical Properties

Formula: C7H6BrNO2  Melting point: 97-101°
Formula weight: 216.04  

Literature References

Has been used as a protecting reagent for the carboxyl group in peptide synthesis: Helv. Chim. Acta, 42, 972 (1959); see 4-Nitrobenzyl­ chloride, A15749, and Appendix 6. Has also been used in ß-lactam synthesis. Cleavage by sodium sulfide avoids hydrogenolysis problems otherwise encountered with these sulfur-containing nuclei: J. Org. Chem., 43, 1243 (1978).

For the protection of alcohols, introduction of the group by the use of silver oxide has been recommended. Selective cleavage can be accomplished with DDQ (2,3-Dichloro-5,6-dicyanobenzoquinone, A11879) or by anodic oxidation. Many other benzyl-type protecting groups are unaffected by these conditions: Tetrahedron Lett., 31, 389 (1990). Indium metal in the presence of ammonium chloride is an effective deprotection system for 4-nitrobenzyl ethers and esters: J. Chem. Soc., Perkin 1, 955 (2001).

Other References

Beilstein: 742796
UN#: UN3261
Harmonized Tariff Code: 2904.90

GHS Hazard and Precautionary Statements

Hazard Statements : H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements : P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A

Do not breathe dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.


Risk & Safety

Risk Phrases: 34
Causes burns.
Safety Phrases: 26-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
RTECS: XS7967000