Hydroxylamine hydrochloride, 99%

CAS Number 5470-11-1 Synonyms
  • Hydroxylammonium chloride

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Hydroxylamine hydrochloride, 99%

MDL: MFCD00051089
EINECS: 226-798-2

Chemical Properties

Formula: H3NO•HCl  Density: 1.67
Formula weight: 69.49  Sensitivity: Hygroscopic
Melting point: 152° dec. 

Literature References

For examples of preparation of oximes from carbonyl compounds, see: Org. Synth. Coll., 2, 70, 313 (1955); 7, 149 (1990). Dehydration of aldoximes is a valuable route to nitriles. The preparation of an oxime, and dehydration with acetic anhydride, are exemplified for veratraldehyde: Org. Synth. Coll., 2, 622 (1943). For other methods of dehydrating oximes to nitriles, see Benzaldoxime, A12053. Procedures for the one-pot conversion of aldehydes to nitriles, without isolation of the intermediate oxime, include: refluxing the aldehyde with hydroxylamine hydrochloride in formic acid/ sodium acetate: J. Chem. Soc., 1564 (1965); formic acid alone: Synthesis, 112 (1979); in pyridine and toluene, with azeotropic water removal: Synthesis, 190 (1982); in DMF (reflux; aromatics only): Z. Chem., 15, 302 (1975); heating in NMP at 110-115o, effective for aromatic and aliphatic substrates; under these conditions, DMF gave only 20-30% conversion: Synthesis, 586 (1999). A more recent ambient temperature one-pot procedure utilizes DBU in combination with ethyl dichlorophosphate: Synlett, 1317 (2007).

For a one-pot synthesis of pyrazoles from aldehydes by cyclization of the intermediate oxime in acidic medium with potassium dihyrogen phosphate, see: Tetrahedron Lett., 47, 43 (2006).

For a brief feature on uses of this reagent in Organic synthesis, see: Synlett, 1326 (2007).


A monoamine oxidase inhibitor

GHS Hazard and Precautionary Statements

Hazard Statements : H351-H373-H290-H315-H319-H400-H302-H312-H317

Suspected of causing cancer. May cause damage to organs through prolonged or repeated exposure. May be corrosive to metals. Causes skin irritation. Causes serious eye irritation. Very toxic to aquatic life. Harmful if swallowed. Harmful in contact with skin. May cause an allergic skin reaction.

Precautionary Statements : P280H-P273-P406

Wear protective gloves/clothing. Avoid release to the environment. Store in corrosive resistant container with a resistant inner liner.

CorrosiveHarmful or IrritantHealth HazardDangerous for the environment

Other References

Merck: 14,4828
Beilstein: 3539763
UN#: UN2923
Hazard Class: 8
Packing Group: III
Harmonized Tariff Code: 2825.10
RTECS: NC3675000


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