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Pentafluorophenol, 99% - CAS 771-61-9 - Formula C6HF5O

A15574 771-61-9 Pentafluorophenol, 99% PFP Alfa Aesar


Certificate of Analysis

Pentafluorophenol, 99%

CAS: 771-61-9 MDL: MFCD00002156  EINECS: 212-235-8
UN#:UN3261Hazard Class:8Packing Group:II
Alternate Name: PFP


Pricing and Availability

Size ($) Price Your Price Quantity Options Availability
5g 27.90 Check Availability Add to Favorites Enter qty and click checkbox
25g 107.00 Check Availability Add to Favorites Enter qty and click checkbox
100g 347.00 Check Availability Add to Favorites Enter qty and click checkbox

Chemical Properties

Formula: C6HF5O  Flash point: 72°(161°F)
Formula weight: 184.06  Density: 1.757
Melting point: 32-36° Refractive Index: 1.4270
Boiling point: 143° 

Literature References

Widely used for peptide coupling (see Appendix 6) via the active PFP esters, generally prepared by carbodiimide coupling: Liebigs Ann. Chem., 1421 (1973); Tetrahedron Lett., 1785 (1974). With Fmoc-protected amino acids, the coupling takes place very rapidly, which reduces the amount of Fmoc-cleavage during the peptide bond formation: Synthesis, 325 (1983). Fmoc protected PFP esters have also been applied in solid phase peptide synthesis: Tetrahedron, 44, 843 (1988). PFP esters have been recommended for preparation of derivatives of heterocyclic acids, effective where DCC or DIC alone fail: Synth. Commun., 28, 753 (1998).

For preparation and use of the moderately stable PFP formate as a formylating agent for amines and amino acids, see: Synthesis, 510 (1987).

Other References

Beilstein: 1912584
UN#: UN3261
Harmonized Tariff Code: 2908.19

GHS Hazard and Precautionary Statements

Hazard Statements : H301-H311-H314-H318

Toxic if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements : P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501A

Do not breathe dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.


Risk & Safety

Risk Phrases: 21/22-34
Harmful in contact with skin and if swallowed. Causes burns.
Safety Phrases: 26-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Harmful Corrosive
RTECS: SM6680000