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Pentafluorophenol, 99% - CAS 771-61-9 - Formula C6HF5O


Certificate of Analysis

Pentafluorophenol, 99%

CAS: 771-61-9 MDL: MFCD00002156  EINECS: 212-235-8
UN#:UN3261Hazard Class:8Packing Group:II
Alternate Name: PFP


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Chemical Properties

Formula: C6HF5O  Flash point: 72°(161°F)
Formula weight: 184.06  Density: 1.757
Melting point: 32-36° Refractive Index: 1.4270
Boiling point: 143° 

Literature References

Widely used for peptide coupling (see Appendix 6) via the active PFP esters, generally prepared by carbodiimide coupling: Liebigs Ann. Chem., 1421 (1973); Tetrahedron Lett., 1785 (1974). With Fmoc-protected amino acids, the coupling takes place very rapidly, which reduces the amount of Fmoc-cleavage during the peptide bond formation: Synthesis, 325 (1983). Fmoc protected PFP esters have also been applied in solid phase peptide synthesis: Tetrahedron, 44, 843 (1988). PFP esters have been recommended for preparation of derivatives of heterocyclic acids, effective where DCC or DIC alone fail: Synth. Commun., 28, 753 (1998).

For preparation and use of the moderately stable PFP formate as a formylating agent for amines and amino acids, see: Synthesis, 510 (1987).

Other References

Beilstein: 1912584
UN#: UN3261
Harmonized Tariff Code:   2908.19

GHS Hazard and Precautionary Statements

Hazard Statements : H301-H311-H314-H318

Toxic if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements : P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501A

Do not breathe dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.


Risk & Safety

Risk Phrases: 21/22-34
Harmful in contact with skin and if swallowed. Causes burns.
Safety Phrases: 26-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Harmful Corrosive
RTECS: SM6680000