A15574

Pentafluorophenol, 99%

CAS Number 771-61-9 Synonyms
  • PFP
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Pentafluorophenol, 99%

MDL: MFCD00002156
EINECS: 212-235-8

Chemical Properties

Formula: C6HF5O  Flash point: 72°(161°F)
Formula weight: 184.06  Density: 1.757
Melting point: 32-36° Refractive Index: 1.4270
Boiling point: 143° 

Literature References

Widely used for peptide coupling (see Appendix 6) via the active PFP esters, generally prepared by carbodiimide coupling: Liebigs Ann. Chem., 1421 (1973); Tetrahedron Lett., 1785 (1974). With Fmoc-protected amino acids, the coupling takes place very rapidly, which reduces the amount of Fmoc-cleavage during the peptide bond formation: Synthesis, 325 (1983). Fmoc protected PFP esters have also been applied in solid phase peptide synthesis: Tetrahedron, 44, 843 (1988). PFP esters have been recommended for preparation of derivatives of heterocyclic acids, effective where DCC or DIC alone fail: Synth. Commun., 28, 753 (1998).

For preparation and use of the moderately stable PFP formate as a formylating agent for amines and amino acids, see: Synthesis, 510 (1987).

GHS Hazard and Precautionary Statements

Hazard Statements : H301-H311-H315-H319-H335

Toxic if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements : P261-P301+P310-P305+P351+P338-P361-P405-P501A

Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Toxic

Other References

Beilstein: 1912584
Harmonized Tariff Code: 2908.19
TSCA: Yes
RTECS: SM6680000
Pentafluorophenol, 99% - CAS 771-61-9 - Formula C6HF5O

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