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1,4-Dithio-DL-threitol, 99% - CAS 3483-12-3 - Formula C4H10O2S2


Certificate of Analysis

1,4-Dithio-DL-threitol, 99%

CAS: 3483-12-3 MDL: MFCD00004877  EINECS: 222-468-7
Not regulated for shipping
Alternate Name: Cleland's Reagent DTT racemic


Pricing and Availability

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Chemical Properties

Formula: C4H10O2S2  Boiling point: 125-130°/12mm
Formula weight: 154.25  Flash point: >110°(230°F)
Melting point: 40-43° Sensitivity: Air Sensitive

Literature References

Protective agent for preventing oxidation of thiol groups and reagent for reduction of disulfide groups in proteins: Biochemistry, 3, 480 (1964); 11, 2939 (1972); J. Biol. Chem., 243, 716 (1968); Methods Enzymol., 25, 185 (1967); 143, 246 (1987).


Useful for stabilizing sulfhydryl-containing enzymes

Other References

Merck: 14,3376
Beilstein: 1719757
Harmonized Tariff Code:   2930.90

GHS Hazard and Precautionary Statements

Hazard Statements : H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements : P261-P280-P301+P310-P305+P351+P338-P405-P501A

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.


Risk & Safety

Risk Phrases: 22-36/37/38
Harmful if swallowed. Irritating to eyes, respiratory system and skin.
Safety Phrases: 26-36/37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves. This material and/or its container must be disposed of as hazardous waste.
RTECS: EK1610000