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Methyl 2-acetamidoacrylate, 99% - CAS 35356-70-8 - Formula C6H9NO3

L10049 35356-70-8 Methyl 2-acetamidoacrylate, 99% Ac-DL-Dha-OMe 2-Acetamidoacrylic acid methyl ester Alfa Aesar


Certificate of Analysis

Methyl 2-acetamidoacrylate, 99%

CAS: 35356-70-8 MDL: MFCD00013394  
Not regulated for shipping
Alternate Name: Ac-DL-Dha-OMe
2-Acetamidoacrylic acid methyl ester


Pricing and Availability

Size ($) Price Your Price Quantity Options Availability
1g 44.80 Check Availability Add to Favorites Enter qty and click checkbox
5g 135.00 Check Availability Add to Favorites Enter qty and click checkbox

Chemical Properties

Formula: C6H9NO3  Melting point: 49-51°
Formula weight: 143.14  Boiling point: 103-104°/8mm

Literature References

Building block for amino acid synthesis.

Heck coupling with 4-iodo-3,5-dimethylphenyl acetate, promoted by palladium acetate and Tri(o-tolyl)­phosphine, A12093, is one of the key steps in a convenient asymmetric synthesis of the unnatural amino acid 2,6-dimethyl-L-tyrosine: Synthesis, 741 (1992).

Asymmetric catalytic hydrogenation in supercritical carbon dioxide in the presence of a chiral rhodium catalyst gives the N-acetylalanine methyl ester in 99.5% ee: J. Am. Chem. Soc., 117, 8277 (1995).

Undergoes rhodium-catalyzed addition with potassium organotrifluoroborates to give substituted alanine derivatives: Eur. J. Org. Chem., 69 (2004). In the presence of a Rh-BINAP catalyst, chiral amino acid derivaitives are formed with good ee: Angew. Chem. Int. Ed., 43, 719 (2004).

Other References

Beilstein: 1812208
Harmonized Tariff Code: 2924.29

GHS Hazard and Precautionary Statements

Hazard Statements : H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements : P261-P280-P305+P351+P338-P304+P340-P405-P501A

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Harmful or Irritant

Risk & Safety

Risk Phrases: 36/37/38
Irritating to eyes, respiratory system and skin.
Safety Phrases: 26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable gloves.