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14913-33-8 - trans-Diamminedichloroplatinum(II), Pt 64.5% min - Dichlorodiammineplatinum(II) - Transplatin - 10472 - Alfa Aesar

10472 trans-Diamminedichloroplatinum(II), Pt 64.5% min

CAS-Nummer
14913-33-8
Synonyme
Dichlorodiammineplatinum(II)
Transplatin

Größe Preis ($) Menge Verfügbarkeit
0.25g 44,46
1g 145,80
5g 677,24
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trans-Diamminedichloroplatinum(II), Pt 64.5% min

MDL
MFCD00011623
EINECS
238-980-9

Chemische Eigenschaften

Formel
Cl2H6N2Pt
Molmasse
300.06
Form
Crystalline
Schmelzpunkt
340° dec.
Löslichkeit
Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water.

Anwendungen

trans-Diamminedichloroplatinum(II) acts as a reversible RNA-protein cross-linking agent. It is also used in plating baths. It reacts with DNA after hydrolysis to get both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA.

Bemerkungen

Incompatible with strong oxidizing agents.

Literaturverweise

Tsotsoros, S. D.; Qu, Y.; Farrell, N. P. The reaction of dichlorodiammineplatinum(II), [PtCl2(NH3)2], isomers with zinc fingers. J. Inorg. Biochem. 2015, 143, 117-122.

Wang, Y.; Benzina, A.; Molin, D. G. M.; Akker, N. V. D.; Gagliardi, M.; Koole, L. H. Preparation and structure of drug-carrying biodegradable microspheres designed for transarterial chemoembolization therapy. J. Biomater. Sci., Polym. Ed. 2015, 26 (2), 77-91.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H334-H315-H319-H317-H341-H335

May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. Suspected of causing genetic defects. May cause respiratory irritation.

Sicherheitshinweise: P261-P262-P280h-P305+P351+P338-P308+P313

Avoid breathing dust/fume/gas/mist/vapours/spray. Do not get in eyes, on skin, or on clothing. Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention.

Weitere Referenzen

Harmonized Tariff Code
2843.90
TSCA
No
RTECS
TP2455000

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