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1,5-Cyclooctadiene(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate is used as a catalyst for hydrogenation of mono-, di-, tri-, and tetra-substituted substrates and the isomerization and hydroboration of alkenes. It is also used in isotope exchange reactions, especially the direct exchange of a hydrogen atom with its isotopes deuterium and tritium. Carbonyl groups are also known to direct the hydrogenation by the Crabtree catalyst is highly regioselective.
Seidel, D.; Pleiss, U. Labelling of the guanylate cyclase activator cinaciguat (BAY 58-2667) with carbon-14, tritium and stable isotopes. J. Labelled Compd. Radiopharm. 2010, 53 (3), 130-139.
Chappelle, M. R.; Hawes, C. R. The use of metal-catalysed hydrogen isotope exchange in the contract supply of tritiated compounds. J. Labelled Compd. Radiopharm. 2010, 53 (11-12), 745-751.
Gefahrenhinweise (EU): H315-H319
Causes skin irritation. Causes serious eye irritation.
Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: