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5-Methylcytosine is used as a marker to protect DNA from being cut by native methylation-sensitive restriction enzymes. It is also employed in the production of 4-amino-5-hydroxy-5-methyl-2-oxo-2,5-dihydro-imidazole-1-carbaldehyde.
Hashimoto, H.; Zhang, X.; Vertino, P. M.; Cheng, X. The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations. J. Biol. Chem. 2015, 290 (34), 20723-20733.
Moen, E. L.; Mariani, C. J.; Zullow, H.; Jeff-Eke, M.; Litwin, E.; Nikitas, J. N.; Godley, L. A. New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine. Immunol. Rev. 2015, 263 (1), 36-49.