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623-33-6 - Glycine ethyl ester hydrochloride, 99% - Ethyl glycinate hydrochloride - H-Gly-OEt.HCl - A10315 - Alfa Aesar

A10315 Glycine ethyl ester hydrochloride, 99%

CAS-Nummer
623-33-6
Synonyme
Ethyl glycinate hydrochloride
H-Gly-OEt.HCl

Größe Preis ($) Menge Verfügbarkeit
100g 22,45
500g 63,76
2500g 204,80
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Glycine ethyl ester hydrochloride, 99%

MDL
MFCD00012871
EINECS
210-787-4

Chemische Eigenschaften

Formel
CH3CH2O2CCH2NH2•HCl
Molmasse
139.58
Schmelzpunkt
144-148°
Sensitivität
Hygroscopic
Löslichkeit
Soluble in water (>1000 mg/ml at 20°C), ethanol, DMSO, and methanol.

Anwendungen

Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.

Bemerkungen

Hygroscopic. Store away from oxidizing agents and water/moisture. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Protect from humidity.

Literaturverweise

Zhang, H, et al. Mass spectrometry-based carboxyl footprinting of proteins: method evaluation.Int. J. Mass Spectrom.,2012,31278-86.

Bill Morandi, et al. Iron-Catalyzed Cyclopropanation with Glycine Ethyl Ester Hydrochloride in Water.Org. Lett.,2012,14(8), 2162-2163.

Reacts with ß-diketones to give substituted pyrrole-2-carboxylic esters: Synthesis, 157 (1982):

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H318

Causes serious eye damage.

Sicherheitshinweise: P280-P305+P351+P338-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.

Weitere Referenzen

Beilstein
3594034
Harmonized Tariff Code
2922.49
TSCA
Yes
RTECS
MC0525000

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