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5390-04-5 - 4-Pentyn-1-ol, 97% - 1-Pentyne-5-ol - 4-Pentynyl alcohol - A10405 - Alfa Aesar

A10405 4-Pentyn-1-ol, 97%

CAS-Nummer
5390-04-5
Synonyme
1-Pentyne-5-ol
4-Pentynyl alcohol

Größe Preis ($) Menge Verfügbarkeit
5g 37,90
25g 132,30
100g 409,60
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

4-Pentyn-1-ol, 97%

MDL
MFCD00002974
EINECS
226-383-6

Chemische Eigenschaften

Formel
C5H8O
Molmasse
84.12
Siedepunkt
153-155°
Flammpunkt
62°(143°F)
Dichte
0.907
Brechungsindex
1.4450
Löslichkeit
Miscible with water.

Anwendungen

4-Pentyn-1-ol is widely utilized in ring-opening polymerization reactions. It plays an important role as a starting reagent in stereo selective total synthesis of antimicrobial marine metabolites, ieodomycin A and B. It is also used in the preparation of 3-pent-4-ynyloxy phthalonitrile.

Bemerkungen

Keep away from sources of ignition. Keep the container tightly closed in a dry and well-ventilated place.

Literaturverweise

Readily forms a dilithio-derivative, allowing regioselective C-alkylation in the 5-position without the need for protection of the alcohol function. Thus, alkylation with the THP ether of 5-bromopentanol gives a 10-carbon chain as part of the synthesis of a macrolide pheromone, and in other natural product syntheses: J. Org. Chem., 58, 7535 (1993), and references therein.

/n

Fjermestad, T.; Ho, J. H. H.; Macgregor, S. A.; Messerle, B. A.; Tuna, D. Computational Study of the Mechanism of Cyclic Acetal Formation via the Iridium(I)-Catalyzed Double Hydroalkoxylation of 4-Pentyn-1-ol with Methanol. Organometallics 2011, 30 (3), 618-626.

Møllendal, H.; Dreizler, H.; Sutter, D. H. Structural and Conformational Properties of 4-Pentyn-1-ol As Studied by Microwave Spectroscopy and Quantum Chemical Calculations. J. Phys. Chem. A 2007, 111 (46), 11801-11808.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Sicherheitshinweise: P260-P280g-P305+P351+P338

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Weitere Referenzen

Beilstein
1736712
Harmonized Tariff Code
2905.29
TSCA
No

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