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L-Menthol is used as a cooling agent that strongly activates TRPM8.(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 is a Protein Coding gene). It is used as analgesic (topical), antipruritic agent. It is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics.
UR Juergens, M Stöber, H Vetter. The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases. European journal of medical research.1998, 3, (12) 539-545.
The L-menthyl ester of succinic acid has been used in a chiral synthesis of (1S,2S)-cyclopropanedicarboxylic acid: Org. Synth. Coll., 8, 141 (1993):
One recrystallization gives the pure enantiomer.
Gefahrenhinweise (EU): H303-H315-H318-H335
May be harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.