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1,2,4-Trimethoxybenzene is used as pharmaceutical intermediates.
Sheryl A. Tucker; Hardjanti Darmodjo; William E. Acree; Maximilian Zander; Erich C. Meister; Mary J. Tanga; and Sumio Tokita. Polycyclic Aromatic Nitrogen Heterocycles. Part IV: Effect of Solvent Polarity, Solvent Acidity, Nitromethane and 1,2,4-Trimethoxybenzene on the Fluorescence Emission Behavior of Select Monoaza- and Diazaarenes. Applied Spectroscopy.1992, 46, 1630-1635.
In contrast to 1,3-Dimethoxybenzene, A13380, direct dilithiation with n-BuLi + TMEDA was feasible, giving, after reaction with TMS chloride, the 2,6-disilyl derivative as the major product in 55% yield: J. Org. Chem., 49, 4657 (1984).