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1,4-Dibromobenzene is used in the synthesis of 2,5-dibromoacetophenone, triarylamines and trans- stilbenes. It is widely used as a heavy liquid solvent as well as a motor oil additive. It finds application as an intermediate in the manufacture of organic chemicals such as dyes, pharmaceuticals and flame retardants for polymeric materials.
In the presence of NiCl2, cross-coupling with aryl Grignards gives p-terphenyls: Synthesis, 147 (1990).
Cano, N. H.; Ballari, M. S.; Lopez, A. G.; Santiago, A. N. New Synthesis and Biological Evaluation of Benzothiazole Derivates as Antifungal Agents. J. Agric. Food Chem. 2015, 63 (14), 3681-3686.
Vazdar, M.; Mitchell, A. S.; Warrener, R. N.; Margetic, D. High pressure promoted exchange of guests from hemicarceplexes. Tetrahedron 2015, 71 (4), 550-553.
Gefahrenhinweise (EU): H303-H315-H319-H335
May be harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid release to the environment. Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.