Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

1072-85-1 - 1-Bromo-2-fluorobenzene, 99% - 2-Bromofluorobenzene - A10635 - Alfa Aesar

A10635 1-Bromo-2-fluorobenzene, 99%

CAS-Nummer
1072-85-1
Synonyme
2-Bromofluorobenzene

Größe Preis ($) Menge Verfügbarkeit
25g 44,46
100g 125,66
500g 404,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

1-Bromo-2-fluorobenzene, 99%

MDL
MFCD00000282
EINECS
214-018-3

Chemische Eigenschaften

Formel
C6H4BrF
Molmasse
175.01
Schmelzpunkt
-8°
Siedepunkt
155-157°
Flammpunkt
43°(109°F)
Dichte
1.601
Brechungsindex
1.5340
Löslichkeit
Insoluble in water.

Anwendungen

1-Bromo-2-fluorobenzene is used as a reactant with cyclopenta-1,3-diene to produce 1,4-dihydro-1,4-methano-naphthalene. This reaction will need reagent Mg, and solvent diethyl ether. The reaction time is 3 hours with the temperature of 20°C,

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Stable under recommended storage conditions. Keep away from Strong oxidizing agents .

Literaturverweise

KG Rutherford.; W Redmond. 1-Bromo-2-Fluorobenzene. Organic Syntheses. 1963, 100, (1), 54-62.

M Feuerstein.; H Doucet.; M Santelli. Tetraphosphine/palladium-catalysed Suzuki cross-coupling with sterically hindered aryl bromides and arylboronic acids. Tetrahedron Letters. 2001, 42, (38), 6667-6670.

On treatment with Mg: J. Org. Chem., 49, 4518 (1984), or n-BuLi: Tetrahedron, 48, 4379 (1992), benzyne is generated, which undergoes [4+2] cycloadditions with furans or pyrroles.

Whereas n-BuLi effects bromine-metal exchange, lithiation with LDA at -75o results in deprotonation ortho to F; subsequent reaction with electrophiles provides access to mixed dihalo derivatives such as 3-bromo-2-fluorobenzoic acid: Tetrahedron Lett., 36, 881 (1995). Improved yields are obtained by the use of lithium 2,2,6,6-tetramethylpiperidide (LTMP) as base: Tetrahedron Lett., 37, 6551 (1996).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H226-H302-H319

Flammable liquid and vapour. Harmful if swallowed. Causes serious eye irritation.

Sicherheitshinweise: P280f-P305+P351+P338

Wear protective clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Weitere Referenzen

Beilstein
1071819
Gefahrenklasse
3
Verpackungsgruppe
III
Harmonized Tariff Code
2903.99
TSCA
Yes
RTECS
DA1050000

Empfohlen

Kürzlich angesehen

Chemikalien

Life science

Metalle und Stoffe

Katalysatoren

Forschungs- und Laborbedarf