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Pyridine-4-carboxaldehyde is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties.
Nand K.Singh; Rajesh Tripathi. Synthesis and structural characterization of 3d-metal complexes of pyridine-4-carboxaldehyde thionicotinoyl hydrazone. Transition Metal Chemistry. 1988, 13, (5),346-350
A.Martin; B.Lucke; H.J.Niclas; A.Forster. Vapor-phase oxidation of 4-picoline to pyridine-4-carboxaldehyde on a vanadium phosphate catalysts. Reaction Kinetics and Catalysis Letters. 1991, 43, (2),583-588
In the presence of DBU, converts amines to carbonyl compounds, e.g. benzylamines to benzaldehydes: Synthesis, 756 (1982):
The reaction is also useful for the conversion of ɑ-amino acids to ɑ-keto acids.
Gefahrenhinweise (EU): H227-H315-H319-H317-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.