I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Lithiation with Li 2,2,6,6-tetramethylpiperidide (LTMP) at -75o occurs at the 2-position. The yield of 2-bromo-6-fluorobenzoic acid obtained after carboxylation can be increased to 93% by the use of a base consisting of a 9:1 mixture of LTMP and LDA: Tetrahedron Lett., 37, 6551 (1996)./n
Gefahrenhinweise (EU): H226-H302-H315-H319
Flammable liquid and vapour. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.
Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.