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D-Serine is involved in the biosynthesis of purines, pyrimidines, and other amino acids. D-Serine also is an agonist of glycine site of the NMDA-type glutamate receptor. It also acts as Lacosamide intermediate.
Christian Henneberger; Thomas Papouin; Stéphane H. R. Oliet & Dmitri A. Rusakov. Long-term potentiation depends on release of d-serine from astrocytes.Nature.2009 463, 232-236.
Herman Wolosker; Kevin N. Sheth; Masaaki Takahashi; Jean-Pierre Mothet; Roscoe O. Brady; Christopher D. Ferris and Solomon H. Snyder. Purification of serine racemase: Biosynthesis of the neuromodulator D-serine.Proceedings of the National Academy of Sciences of the United States of America.1999 96, 721-725.
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