Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

6553-96-4 - 2,4,6-Triisopropylbenzenesulfonyl chloride, 98% - Trisyl chloride - A11458 - Alfa Aesar

A11458 2,4,6-Triisopropylbenzenesulfonyl chloride, 98%

CAS-Nummer
6553-96-4
Synonyme
Trisyl chloride

Größe Preis ($) Menge Verfügbarkeit
25g 53,25
100g 167,89
500g 642,93
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

2,4,6-Triisopropylbenzenesulfonyl chloride, 98%

MDL
MFCD00007433
EINECS
229-479-6

Chemische Eigenschaften

Formel
C15H23ClO2S
Molmasse
302.87
Schmelzpunkt
94-97°
Sensitivität
Moisture Sensitive
Löslichkeit
Soluble in chloroform.

Anwendungen

2,4,6-Triisopropylbenzenesulfonyl chloride is used for the synthesis of glycerophospholipids as a condensing agent and in the analysis of phosphonolipids in egg yolk by HPLC/MS technique. It acts as a coupling reagent for the synthesis of oligonucleotides and as sulfonates of pyrimidine nucleosides. It also serves as a condensing agent in the synthesis of hydrogen-phosphonate diesters.

Bemerkungen

Incompatible with strong bases.

Literaturverweise

Hindered sulfonyl chlorides have found use as condensing agents for the formation of the phosphate link of oligonucleotides. For reviews, see: Angew. Chem. Int. Ed., 11, 451 (1972); Synthesis, 222 (1975); Chem. Rev., 77, 183 (1977). For reviews of oligonucleotide synthesis by the phosphotriester method, see: Heterocycles, 7, 1197 (1977); Tetrahedron, 34, 3143 (1978). For use as a condensing agent in the synthesis of H-phosphonate diesters, see: Nucleosides Nucleotides, 7, 23 (1988). More hindered in comparison with, e.g. Mesityl­ene-2-sulfonyl­ chloride, A11775, and so has less tendency to react with the free 5'-hydroxyl group of sugars: J. Am. Chem. Soc., 88, 829 (1966).

For examples of the utility of the triisopropylbenzenesulfonyl group in the protection of OH groups, see: J. Am. Chem. Soc., 117, 5693, 5776 (1995): (first synthesis of a digitalis saponin and asymmetric synthesis of (-) and (+)-strychnine, respectively).

/n

Cai, H.; Liu, Q.; Gao, D.; Wang, T.; Chen, T.; Yan, G.; Chen, K.; Xu, Y.; Wang, H.; Li, Y.; Zhu, W. Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination. Eur. J. Med. Chem. 2015, 90, 241-250.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1218575
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2904.90
TSCA
No

Empfohlen

  • A10565

    Trichloroacetonitrile, 98%
  • A10829

    1,3-Propanediol, 99%
  • A11288

    2,5-Dimethoxybenzenesulfonyl chloride, 98%
  • A11511

    4-Acetamidobenzenesulfonyl chloride, 98+%
  • A14708

    Di-tert-butyl dicarbonate, 97+%

Kürzlich angesehen

Chemikalien

Life science

Metalle und Stoffe

Katalysatoren

Forschungs- und Laborbedarf