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927-74-2 - 3-Butyn-1-ol, 98% - 4-Hydroxy-1-butyne - A11477 - Alfa Aesar

A11477 3-Butyn-1-ol, 98%

CAS-Nummer
927-74-2
Synonyme
4-Hydroxy-1-butyne

Größe Preis ($) Menge Verfügbarkeit
5g 36,67
25g 105,06
250g 797,60
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

3-Butyn-1-ol, 98%

MDL
MFCD00002955
EINECS
213-161-9

Chemische Eigenschaften

Formel
C4H6O
Molmasse
70.09
Schmelzpunkt
-63°
Siedepunkt
129-130°
Flammpunkt
36°(96°F)
Dichte
0.927
Brechungsindex
1.4405
Löslichkeit
Miscible with alcohols and organic solvents. Immiscible with aliphatic hydrocarbon solvents.

Anwendungen

3-butyn-1-ol is used in the study of a palladium-catalyzed coupling with beta-tetrionic acid bromide to prepare alkynyl substituted furanones. It is also used to prepare Markovnikov addition product. Further, it is used as an intermediate of an active pharmaceutical ingredient such as fexofenadine.

Bemerkungen

Incompatible with strong oxidizing agents, acids, acid anhydrides and copper.

Literaturverweise

For examples of Sonogashira coupling with aryl iodides in the presence of trans-Dichlorobis(triphenyl­phosphine)­palladium(II)­, 10491, CuI and Et3N in acetonitrile, see: J. Med. Chem., 38, 1837 (1995).

The triflate ester cyclizes on prolonged reaction with Na trifluoroacetate in TFA to give cyclobutanone: Org. Synth. Coll., 6, 324 (1988).

Yin, S.; Dong, L.; Xia, Y.; Dong, B.; He, X.; Chen, D.; Qiu, H.; Song, B. Controlled self-assembly of a pyrene-based bolaamphiphile by acetate ions: from nanodisks to nanofibers by fluorescence enhancement. Soft matter 2015, 11 (22), 4424-4429.

Tan, W.; Li, Q.; Li, W.; Dong, F.; Guo, Z. Synthesis and antioxidant property of novel 1, 2, 3-triazole-linked starch derivatives via ‘click chemistry’. Int. J. Biol. Macromol. 2016, 82, 404-410.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280g-P305+P351+P338

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Weitere Referenzen

Beilstein
773710
Gefahrenklasse
3
Verpackungsgruppe
III
Harmonized Tariff Code
2905.29
TSCA
Yes
RTECS
ES0710000

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