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383-63-1 - Ethyl trifluoroacetate, 99% - Trifluoroacetic acid ethyl ester - A11520 - Alfa Aesar

A11520 Ethyl trifluoroacetate, 99%

CAS-Nummer
383-63-1
Synonyme
Trifluoroacetic acid ethyl ester

Größe Preis ($) Menge Verfügbarkeit
50g 41,41
250g 164,70
1000g 663,32
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Ethyl trifluoroacetate, 99%

MDL
MFCD00000419
EINECS
206-851-6

Chemische Eigenschaften

Formel
C4H5F3O2
Molmasse
142.08
Schmelzpunkt
<-78°
Siedepunkt
60-62°
Flammpunkt
-1°(30°F)
Dichte
1.192
Brechungsindex
1.3070
Sensitivität
Moisture Sensitive
Löslichkeit
Slightly miscible with water. Miscible with chloroform and methanol.

Anwendungen

Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products. It is also useful for the preparation of tri fluoroacylated compounds.

Bemerkungen

Moisture Sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents, strong bases and strong acids.

Literaturverweise

Reagent for selective trifluoroacetylation of amines. Primary amines can be protected in the presence of secondary, and diamines selectively monoprotected. Primary amines can also be differentiated in terms of steric hindrance: Tetrahedron Lett., 36, 7357 (1995).

Esters of perfluoroalkyl carboxylic acids undergo Wittig reactions, for example with the ylide from (3-Phenyl­propyl)­triphenyl­phosphonium bromide, A12669, leading to 1-perfluoroalkyl enol ethers, which are useful precursors of various fluorinated derivatives: J. Org. Chem., 57, 3807 (1992); Org. Synth., 75, 153 (1997):

Bhattacharjee, D.; Tiwari, L.; Singh, H. J.; Mishra, B. K.; Deka, R. C. Theoretical investigation on mechanism, kinetics and thermochemistry of gas-phase reactions of ethyl trifluoroacetate with OH radicals. J. Fluorine Chem. 2015, 178, 79-85.

Huang, Z.; Jiang, H.; Li, L.; Wang, H.; Qiu, T. Density, viscosity, and saturated vapor pressure of ethyl trifluoroacetate. J. Chem. Thermodyn. 2015, 86, 75-79.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1761411
Gefahrenklasse
3
Verpackungsgruppe
II
Harmonized Tariff Code
2915.90
TSCA
Yes

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