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103-72-0 - Phenyl isothiocyanate, 97% - A11596 - Alfa Aesar

A11596 Phenyl isothiocyanate, 97%

CAS-Nummer
103-72-0
Synonyme

Größe Preis ($) Menge Verfügbarkeit
5g 22,87
100g 37,70
500g 121,50
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Phenyl isothiocyanate, 97%

MDL
MFCD00004798
EINECS
203-138-1

Chemische Eigenschaften

Formel
C7H5NS
Molmasse
135.19
Schmelzpunkt
-21°
Siedepunkt
220-221°
Flammpunkt
87°(188°F)
Dichte
1.131
Brechungsindex
1.6500
Sensitivität
Moisture Sensitive
Löslichkeit
Soluble in alcohol, and ether. Insoluble in water.

Anwendungen

Phenyl isothiocyanate acts as a derivatizing reagent for primary and secondary amines. It is used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC. It is used for derivatizing N-terminal amino acids of proteins for automated sequential analysis. It is a synthon for dithiadiazafulvalenes.

Bemerkungen

Moisture Sensitive. Protect from humidity and water. Store under dry inert gas away from oxidizing agents and moisture. Store at 4°C.

Literaturverweise

F Lai; T Sheehan. Matrix effects in the derivatization of amino acids with naphthalene dicarboxaldehyde, 9-fluorenylmethyl chloroformate and phenylisothiocyanate. BioTechniques.1993, 14 (4), 642-649.

Mark C Wesley; Luis M Pereira; Laurie A Scharp; Sitaram M Emani; Francis X McGowan; James A DiNardo. Pharmacokinetics of tranexamic acid in neonates, infants, and children undergoing cardiac surgery with cardiopulmonary bypass. Anesthesiology.2015, 122 (4), 746-758.

Derivatizing agent for amino groups. Introduced by Edman for the determination of amino acid sequence by conversion to the thiourea, acid cleavage of the peptide bond and alkaline hydrolysis of the derived thiohydantoin: Acta Chem. Scand., 4, 277 (1950); Arkiv. Kemi., 14, 291 (1959). The thiourea can also be cleaved with TFA: Nature, 227, 716 (1970), or by peracid oxidation: Chem. Ber., 89, 2288 (1956).

For general reactions of isothiocyanates, see Appendix 3.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H317-H334-H314-H318-H400-H410-H227

Toxic if swallowed. May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects. Combustible liquid.

Sicherheitshinweise: P210-P260-P285-P261-P301+P310-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,7297
Beilstein
471392
Gefahrenklasse
6.1
Verpackungsgruppe
II
Harmonized Tariff Code
2930.90
TSCA
Yes
RTECS
NX9275000

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