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372-48-5 - 2-Fluoropyridine, 99% - A11627 - Alfa Aesar

A11627 2-Fluoropyridine, 99%

CAS-Nummer
372-48-5
Synonyme

Größe Preis ($) Menge Verfügbarkeit
10g 29,61
25g 58,87
100g 193,64
250g 341,49
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

2-Fluoropyridine, 99%

MDL
MFCD00006224
EINECS
206-757-5

Chemische Eigenschaften

Formel
C5H4FN
Molmasse
97.09
Siedepunkt
124-126°
Flammpunkt
24°(75°F)
Dichte
1.129
Brechungsindex
1.4670
Löslichkeit
Soluble in water.

Anwendungen

2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.

Bemerkungen

Store in a cool, dry, well-ventilated area away from incompatible substances such as oxidizing agents.

Literaturverweise

Lubov Pasumansky; Armando R. Hernández; Soya Gamsey; Christian T. Goralskib; Bakthan Singaram. Synthesis of aminopyridines from 2-fluoropyridine and lithium amides. Tetrahedron Letters.2004, 45 413-417.

The possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine makes 2-fluoropyridine a useful precursor of a wide range of 2,3-disubstituted pyridines. See, e.g.: J. Org. Chem., 53, 2740 (1988):

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1515
Gefahrenklasse
3
Verpackungsgruppe
III
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
UT3900000

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