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460-00-4 - 1-Bromo-4-fluorobenzene, 99% - 4-Bromofluorobenzene - A11630 - Alfa Aesar

A11630 1-Bromo-4-fluorobenzene, 99%

CAS-Nummer
460-00-4
Synonyme
4-Bromofluorobenzene

Größe Preis ($) Menge Verfügbarkeit
100g 43,67
500g 130,81
2500g 515,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

1-Bromo-4-fluorobenzene, 99%

MDL
MFCD00000342
EINECS
207-300-2

Chemische Eigenschaften

Formel
C6H4BrF
Molmasse
175.01
Schmelzpunkt
-16°
Siedepunkt
151-153°
Flammpunkt
60°(140°F)
Dichte
1.604
Brechungsindex
1.5270
Löslichkeit
Soluble in water(0.14g/L).

Anwendungen

1-Bromo-4-fluorobenzene is used as an intermediate in the synthesis of atypical antipsychotic agents.

Bemerkungen

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literaturverweise

Xi-Bin Gu.; Guang-Jun Wang.; Jian-Hua Huang.; Ke-Li Han.; Guo-Zhong He.; Nan-Quan Lou. Photofragment Translational Spectroscopy of 1-Bromo-3-fluorobenzene and 1-Bromo-4-fluorobenzene at 266 nm. J. Phys. Chem. 2001, 105, (2), 354-362.

Kuniaki Kawataa.; Tsuyoshi Ibarakia.; Akiko Tanabea.; Hiroaki Yagoha.; Akiko Shinodab.; Hiroshi Suzukib.; Akio Yasuhara. Gas chromatographic-mass spectrometric determination of hydrophilic compounds in environmental water by solid-phase extraction with activated carbon fiber felt. Journal of Chromatography A. 2001, 911, (1), 75-83.

The Br undergoes selective displacement with Na alkoxides in NMP, in the presence of CuBr: Tetrahedron, 48, 3633 (1992).

Lithiation with LDA at -75o results mainly in deprotonation ortho to F; subsequent reaction with CO2 gives 5-bromo-2-fluorobenzoic acid: Tetrahedron Lett., 33, 7495 (1992). Improved yields are obtained by the use of Li 2,2,6,6-tetramethylpiperidide (LTMP) as base: Tetrahedron Lett., 37, 6551 (1996).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H226-H332-H319-H313

Flammable liquid and vapour. Harmful if inhaled. Causes serious eye irritation. May be harmful in contact with skin.

Sicherheitshinweise: P261-P305+P351+P338

Avoid breathing dust/fume/gas/mist/vapours/spray. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Weitere Referenzen

Beilstein
774102
Gefahrenklasse
3
Verpackungsgruppe
III
Harmonized Tariff Code
2903.99
TSCA
Yes
RTECS
CY9033750

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