I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
4-Nitrobenzaldehyde is used in the preparation of homoallylic alcohols. It is also involved in the development and evaluation of a series of tripeptide organocatalysts.
1,3-Oxathiolanes (see 2-Mercaptoethanol, A15890) can be selectively cleaved in the presence of dithioacetals using 4-nitrobenzaldehyde catalyzed by TMS-OTf: J. Chem. Soc., Chem. Commun., 1937 (1994). This combination has been used for conversion of thioketones to ketones: Tetrahedron Lett., 36, 2277 (1995).
Kapoor, M.; Majumder, A. B.; Gupta, M. N. Promiscuous Lipase-Catalyzed C-C Bond Formation Reactions Between 4 Nitrobenzaldehyde and 2-Cyclohexen-1-one in Biphasic Medium: Aldol and Morita-Baylis-Hillman Adduct Formations. Catal. Lett. 2015, 145 (2), 527-532.
Verma, N.; Kundi, V.; Ahmed, N. Piperidine-mediated annulation of 2-acylphenols with 4-nitrobenzaldehyde to 3-benzofuranones. Tetrahedron Lett. 2015, 56 (28), 4175-4179.
Gefahrenhinweise (EU): H303-H319-H317
May be harmful if swallowed. Causes serious eye irritation. May cause an allergic skin reaction.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Wash contaminated clothing before reuse. Dispose of contents/container in accordance with local/regional/national/international regulations.