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3112-85-4 - Methyl phenyl sulfone, 98+% - A11727 - Alfa Aesar

A11727 Methyl phenyl sulfone, 98+%

CAS-Nummer
3112-85-4
Synonyme

Größe Preis ($) Menge Verfügbarkeit
10g 54,38
50g 178,20
250g 704,00
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Methyl phenyl sulfone, 98+%

MDL
MFCD00014741
EINECS
221-476-8

Chemische Eigenschaften

Formel
C7H8O2S
Molmasse
156.20
Schmelzpunkt
85-88°
Löslichkeit
Soluble in methanol, ethanol, benzene, and chloroform. Partly miscible in water.

Anwendungen

Methyl phenyl sulfone, a versatile building block for the construction of chemicals with diverse functionalities

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literaturverweise

Marc Julia; Dominique Deprez. Syntheses a l'aide de sulfones XIII. Transpositions stereoselectives des alcools α-allyliques β?-sulfones. Tetrahedron Letters. 1976, 17 (4), 277-280.

Gerald W. Buchanan; Cesar Reyes-Zamora; Douglas E. Clarke. A Carbon-13 Nuclear Magnetic Resonance Investigation of Some Substituted Methyl Phenyl Sulfides, Sulfoxides, and Sulfones. Canadian Journal of Chemistry. 1974, 52 (23), 3895-3904.

Factors governing the selective alkylation have been studied. Lithium bases favor dialkylation. For monoalkylation, a potassium base, e.g. KH in THF, should be used: J. Org. Chem., 55, 2234 (1990).

Adds to aldehydes and ketones in the presence of base, e.g. n-BuLi, to give ß-hydroxy sulfones. Conversion of the OH to, e.g. to mesylate, and elimination/desulfurative reduction with sodium amalgam provides a 1-substitued or 1,1-disubstituted alkene by the Julia olefination reaction: Tetrahedron Lett., 4833 (1973); J. Chem. Soc., Perkin 1, 829 (1978). For reaction scheme, see Ethyl­ phenyl­ sulfone, A10710. The adducts with aldehydes can also be rearranged to give the dimethyl acetals of the homologous aldehydes: J. Chem. Soc., Perkin 1, 1646 (1978). Reaction with acyl halides gives ß-keto sulfones: J. Org. Chem., 53, 906 (1988).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302

Harmful if swallowed.

Sicherheitshinweise: P264-P270-P301+P312-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1906914
Harmonized Tariff Code
2930.90
TSCA
No
RTECS
WR6800000

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