I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Stock No. | Größe | Preis ($) | Menge | Verfügbarkeit |
---|---|---|---|---|
A11829-30 | 250g | 37,90 |
|
|
A11829-36 | 500g | 61,50 |
|
|
A11829-0E | 2500g | 244,00 |
|
|
A11829-0C | 10000g | 925,00 |
|
|
N-Methylformanilide is used as a formylating reagent for certain organometallics. It is in combination with phosphoryl chloride used for Vilsmeier-Haack reactions and in heterocycle syntheses. Further, it acts as a swelling agent in the dyeing process of meta-aramid fibers.
Component of Vilsmeier's original reagent for the formylation of reactive aromatics via the iminium salts: Ber., 60, 119 (1927); much used in earlier work, where N,N-Dimethylformamide, A13547 , is often now preferred due to lower cost, greater thermal stability of the iminium salt and easier separation of the by-products (water-soluble in the case of DMF). The N-methylformanilide reagent is still occasionally preferred because of its higher electrophilic potential, although this may be partially offset by its greater steric demand. For examples of its use, see: Org. Synth. Coll., 3, 96 (1955); 4, 915 (1963). Review: Adv. Org. Chem., 9, 225 (1976). Monograph: Synthesis Using Vilsmeier Reagents, C. M. Marson, P. R. Giles, CRC Press, Boca Raton, FL (1994).
Has also been used for the conversion of aryllithiums to aldehydes: J. Chem. Soc. (C), 1700 (1969).
Islam, M. T.; Aimone, F.; Ferri, A.; Rovero, G. Use of N-methylformanilide as swelling agent for meta-aramid fibers dyeing: Kinetics and equilibrium adsorption of Basic Blue 41. Dyes Pigm. 2015, 113, 554-561.
Zhang, J.; Wang, Y.; Luo, N.; Chen, Z.; Wu, K.; Yin, G. Redox inactive metal ion triggered N-dealkylation by an iron catalyst with dioxygen activation: a lesson from lipoxygenases. Dalton Trans. 2015, 44 (21), 9847-9859.
Gefahrenhinweise (EU): H302-H317
Harmful if swallowed. May cause an allergic skin reaction.
Sicherheitshinweise: P261-P280g-P301+P312a-P363-P321-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Wash contaminated clothing before reuse. Specific treatment (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.