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327-52-6 - 1-Bromo-2,4,5-trifluorobenzene, 98+% - 2,4,5-Trifluorobromobenzene - A11962 - Alfa Aesar

A11962 1-Bromo-2,4,5-trifluorobenzene, 98+%

CAS-Nummer
327-52-6
Synonyme
2,4,5-Trifluorobromobenzene

Größe Preis ($) Menge Verfügbarkeit
1g 17,46
5g 41,31
25g 163,80
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1-Bromo-2,4,5-trifluorobenzene, 98+%

MDL
MFCD00000306
EINECS
206-318-8

Chemische Eigenschaften

Formel
C6H2BrF3
Molmasse
210.98
Schmelzpunkt
-19°
Siedepunkt
143-144°
Flammpunkt
55°(131°F)
Dichte
1.806
Brechungsindex
1.4860
Löslichkeit
Insoluble in water.

Anwendungen

1-Bromo-2,4,5-trifluorobenzene is the intermediate of liquid crystals. The derivatives of this compound can be used as intermediates for the synthesis of qunolone antibacterial. It is employed in the synthesis of 3-ethenyl, 3-ethynyl, 3-aryl, and 3-cyclopropyl-2, 4, 5-trifluorobenzoic acids from 1-bromo-2, 4, 5-trifluorobenzene and 2, 4, 5-trifluoro-3-hydroxybenzoic acid.

Bemerkungen

Store at room temperature. Keep away from oxidizing agents.

Literaturverweise

William R. Turner.; Mark J. Suto. 3-Ethenyl, 3-ethynyl, 3-aryl, and 3-cyclopropyl-2,4,5-trifluorobenzoic acids: Useful intermediate in the synthesis of quinolone antibacterials. Tetrahedron Lett. 1993, 34 (2),281-284.

H.-J. Frohn.; H. Franke.; P. Fritzen.; V.V. Bardin. (Fluoroorgano)fluoroboranes and -fluoroborates I: synthesis and spectroscopic characterization of potassium fluoroaryltrifluoroborates and fluoroaryldifluoroboranes. J. Organomet. Chem. 2000, 598 (1),127-135.

Lithiation with LDA occurs selectively at the 3-position, and has been exploited in the synthesis of 8-(trifluoromethyl)-substituted quinolines as antibacterial agents: J. Med. Chem., 35, 361 (1992). For a study of lithiation under various conditions, see: J. Chem. Soc., Perkin 1, 2729 (1995).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1636588
Gefahrenklasse
3
Verpackungsgruppe
III
Harmonized Tariff Code
2903.99
TSCA
No

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