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4-Fluoroiodobenzene was used in the preparation of fluorotriphenylene derivatives. 4-[F] Fluoroiodobenzene is a versatile building block in 18F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions.
Jerry M. Meyersa.; Andrew J. Gellman. Effect of substituents on the phenyl coupling reaction on Cu(111).Surface Science. 1995, 337 (1-2), 40-50.
Hülya Akgün.; Tomas Hudlicky. Total syntheses of ert-conduramine A and ent-7-deoxypancratistatin. Tetrahedron Lett. 1999, 40 (16),3081-3084.
Regioselective metallation can be accomplished with LDA ortho to the fluoro substituent: Tetrahedron Lett., 33, 7499 (1992). Subsequent carboxylation and F - displacement with an amine has been used to synthesize 5-iodoanthranilic acid derivatives: J. Med. Chem., 40, 717 (1997).
Gefahrenhinweise (EU): H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
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