I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
N,O-Bis(trimethylsilyl)trifluoroacetamide is used as a derivatization reagent for gas chromatography and mass-spectrometry analysis of phenolic acids in fruits. It is also used as a reactant in the preparation of pyrimidinone ribosides and analogs which shows anti-tumor properties. It plays as an important role as a reagent for the regioselective desulfation of polysaccharide sulfates. Furthermore, it is used to prepare trimethylsilyl ethers of carbohydrates and alcohols.
Powerful silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions, similar to N,O-Bis(trimethylsilyl)acetamide, L00183, with the advantage that both the reagent and its by-product, trifluoroacetamide, are more volatile than the corresponding non-fluorinated analogues: Biochem. Biophys. Res. Commun., 31, 616 (1968). See Appendix 4.
Sagona, J. A.; Dukett, J. E.; Hawley, H. A.; Mazurek, M. A. Sequential derivatization of polar organic compounds in cloud water using O-(2, 3, 4, 5, 6-pentafluorobenzyl) hydroxylamine hydrochloride, N, O-bis (trimethylsilyl) trifluoroacetamide, and gas-chromatography/mass spectrometry analysis. J. Chromatogr. A 2014, 1362, 16-24.
Irei, S.; Rudolph, J.; Huang, L. Compound-specific stable carbon isotope ratios of phenols and nitrophenols derivatized with N, O-bis (trimethylsilyl) trifluoroacetamide. Anal. Chim. Acta 2013, 786, 95-102.
Gefahrenhinweise (EU): H226-H314-H318
Flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.