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92-43-3 - 1-Phenyl-3-pyrazolidinone, 97% - Phenidone - A12089 - Alfa Aesar

A12089 1-Phenyl-3-pyrazolidinone, 97%

CAS-Nummer
92-43-3
Synonyme
Phenidone

Größe Preis ($) Menge Verfügbarkeit
50g 23,40
250g 97,20
1000g 319,00
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1-Phenyl-3-pyrazolidinone, 97%

MDL
MFCD00003094
EINECS
202-155-1

Chemische Eigenschaften

Formel
C9H10N2O
Molmasse
162.19
Schmelzpunkt
120-123°
Löslichkeit
Soluble in water (1:10 hot), methanol (0.1 mg/mL), DMSO (75 mg/mL), and ethanol.

Anwendungen

Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.

Bemerkungen

Store in cool place. Keep away from oxidizing agents.

Literaturverweise

Dennis J. Hlasta.; Francis B. Casey.; Edward W. Ferguson.; Sally J. Gangell.; Martha R. Heimann.; Edward P. Jaeger.; Rudolph K. Kullnig.; Robert J. Gordon. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J. Med. Chem. 1991, 34 (5),1560-1570.

Hong-Jun Wang.; Jeffrey Keilman.; Chittari Pabba.; Zhen-Jia Chen.; Brian T. Gregg. Microwave-assisted cross-coupling of 3-chloro-2-pyrazolines and 3-chloro-1-phenyl-1,4,5,6-tetrahydropyridazine with aryl boronic acids. Tetrahedron Lett. 2005, 46 (15),2631-2634.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H411-H401

Harmful if swallowed. Toxic to aquatic life with long lasting effects. Toxic to aquatic life.

Sicherheitshinweise: P273-P264-P270-P301+P312-P330-P391-P501a

Avoid release to the environment. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Collect spillage. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,7309
Beilstein
131856
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2933.19
TSCA
Yes
RTECS
UQ8750000

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