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4-Iodoanisole is used in wide range of medicals industrial applications as well as in human and animal nutrition products, pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals. Iodine derivatives are also used as organic building blocks, analytical reagents.
Noel S. Murcia; Dennis G. Peters. Electroreductive carboxylation of halobenzenes. Production of p-anisic acid by reduction of p-iodoanisole at mercury in dimethylformamide saturated with carbon dioxide. J. Electroanal. Chem. 1992, 326 (1-2), 69-79.
Gertrude Maud Robinson. LXXVII.Experiments on the so-called migration of atoms and groups. Part I. The nitration of p-iodoanisole and other iodo-phenolic ethers. J. Chem. Soc., Trans. 1916, 109, 1078-1091.
For use in the 'ligandless' Suzuki cross-coupling with arylboronic acids, see: Org. Synth., 75, 61 (1997).
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.