I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.
K. D. Senali Abayratna Wansa; Jonathan M. Harris; Grace Yan; Peter Ordentlich and George E. O. Muscat. The AF-1 Domain of the Orphan Nuclear Receptor NOR-1 Mediates Trans-activation, Coactivator Recruitment, and Activation by the Purine Anti-metabolite 6-Mercaptopurine. The Journal of Biological Chemistry. 1986, 278, 24776-24790.
John A. Montgomery; Thomas P. Johnston; Anne Gallagher; Carl R. Stringfellow; Frank M. SchabelJr. A Comparative Study of the Anticancer Activity of Some S-Substituted Derivatives of 6-Mercaptopurine and their Ribonucleosides. J. Med. Chem. 1960, 3 (2), 265-288.
Gefahrenhinweise (EU): H302-H341-H361
Harmful if swallowed. Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child.
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.