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6112-76-1 - 6-Mercaptopurine monohydrate, 98% - 6-Purinethiol monohydrate - A12197 - Alfa Aesar

A12197 6-Mercaptopurine monohydrate, 98%

CAS-Nummer
6112-76-1
Synonyme
6-Purinethiol monohydrate

Größe Preis ($) Menge Verfügbarkeit
1g 20,70
5g 62,11
25g 177,60
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6-Mercaptopurine monohydrate, 98%

MDL
MFCD03854445
EINECS
200-037-4

Chemische Eigenschaften

Formel
C5H4N4S•H2O
Molmasse
170.19 (152.17anhy)
Schmelzpunkt
ca 315° dec.
Löslichkeit
Soluble in dilute solutions of alkali hydroxides, hot alcohol, and 1 N NaOH (50 mg/ml). Insoluble in water.

Anwendungen

6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.

Bemerkungen

Store in cool, dry place, in well sealed container. Store away from oxidizing agents.

Literaturverweise

K. D. Senali Abayratna Wansa; Jonathan M. Harris; Grace Yan; Peter Ordentlich and George E. O. Muscat. The AF-1 Domain of the Orphan Nuclear Receptor NOR-1 Mediates Trans-activation, Coactivator Recruitment, and Activation by the Purine Anti-metabolite 6-Mercaptopurine. The Journal of Biological Chemistry. 1986, 278, 24776-24790.

John A. Montgomery; Thomas P. Johnston; Anne Gallagher; Carl R. Stringfellow; Frank M. SchabelJr. A Comparative Study of the Anticancer Activity of Some S-Substituted Derivatives of 6-Mercaptopurine and their Ribonucleosides. J. Med. Chem. 1960, 3 (2), 265-288.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H341-H361-H302

Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child. Harmful if swallowed.

Sicherheitshinweise: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,5871
Beilstein
4012091
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
UP0400000

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