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4-Methoxy-o-phenylenediamine is widely used as an intermediate in organic synthesis and pharmaceuticals. It is an important precursor for the synthesis of other heterocyclic compounds. It is used in the determination of glyoxal, methylglyoxal, and diacetyl in urine using 4-methoxy-o-phenylenediamine as derivatizing reagent by High-performance liquid chromatography (HPLC).
Escobosa, A. R. C.; Ojeda, A. G.; Wrobel, K.; Magana, A. A.; Wrobel, K. Methylglyoxal is associated with bacteriostatic activity of high fructose agave syrups. Food Chem. 2014, 165, 444-450.
Ojeda, A. G.; Escobosa, A. R. C.; Wrobel, K.; Barrientos, E. Y.; Wrobel, K. Effect of Cd(II) and Se(IV) exposure on cellular distribution of both elements and concentration levels of glyoxal and methylglyoxal in Lepidium sativum. Metallomics 2013, 5 (9), 1254-1261.
Gefahrenhinweise (EU): H302-H312-H332-H315-H319-H335
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.