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It is used as a research tool, in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis. In the laboratory, 4-AP is a useful pharmacological tool in studying various potassium conductances in physiology and biophysics. Spinal cord injury patients have also seen improvement with 4-AP therapy.
H Bostock et. al.The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibres. Journal of Physiology. 1981, 313 301-315.
Shun-ichi Yamaguchi,; Michael A. Rogawski.Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice . Epilepsy Research. 1992, 11(1), 9-16.
Gefahrenhinweise (EU): H300-H311-H315-H319-H335
Fatal if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid release to the environment. Wear protective gloves/clothing. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF ON SKIN: Wash with plenty of water.