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91-56-5 - Isatin, 98% - 2,3-Indolinedione - A12468 - Alfa Aesar

A12468 Isatin, 98%

CAS-Nummer
91-56-5
Synonyme
2,3-Indolinedione

Größe Preis ($) Menge Verfügbarkeit
100g 21,22
500g 75,19
2500g 294,58
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Isatin, 98%

MDL
MFCD00005718
EINECS
202-077-8

Chemische Eigenschaften

Formel
C8H5NO2
Molmasse
147.13
Schmelzpunkt
ca 199-200°
Flammpunkt
220°(428°F)
Löslichkeit
Soluble in water (1.9 g/L at 20°C).

Anwendungen

Isatin is an endogenous monoamine oxidize (MAO) inhibitor involved in stress and anxiety. Additionally, isatin inhibits alkaline phosphatase (ALP), nitric oxide (NO)-stimulated soluble guanylate cyclase, and other enzymes. Isatins undergo a one-pot Wolff-Kishner like reduction with hydrazine hydrate, under surprisingly mild conditions, to give the corresponding oxindoles. It is used as chromatographic spray reagent for amino acid detection.

Bemerkungen

Store under cool dry place. Ensure good ventilation. Incompatible with oxidizing agents.

Literaturverweise

Seshaiah Krishnan Sridhar.; Surendra N Pandey.; James P Stables.; Atmakuru Ramesh. Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives. European Journal of Pharmaceutical Sciences. 2002, 16 (3),129-132.

S.N. Pandeya.; D. Sriram.; G. Nath.; E. DeClercq. Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4?-chlorophenyl)thiazol-2-yl] thiosemicarbazide. European Journal of Pharmaceutical Sciences. 1999, 9 (1),25-31.

Isatins undergo a one-pot Wolff-Kishner like reduction with hydrazine hydrate, under surprisingly mild conditions, to give the corresponding oxindoles: Synth. Commun., 24, 2835 (1994).

Reaction with acid anhydrides or condensation with 4-Methyl-2-pentanone, A11618, results in the formation of quinoline-4-carboxylic acid derivatives; for examples, see: J. Med. Chem., 35, 4893 (1992); 36, 617, 3286 (1993).:

Weitere Referenzen

Merck
14,5104
Beilstein
383659
Harmonized Tariff Code
2933.79
TSCA
Yes
RTECS
NL7873000

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