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2226-96-2 - 4-Hydroxy-TEMPO, free radical, 98+% - 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical - A12497 - Alfa Aesar

A12497 4-Hydroxy-TEMPO, free radical, 98+%

CAS-Nummer
2226-96-2
Synonyme
4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical

Größe Preis ($) Menge Verfügbarkeit
1g 25,10
5g 67,00
25g 261,00
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4-Hydroxy-TEMPO, free radical, 98+%

MDL
MFCD00006478
EINECS
218-760-9

Chemische Eigenschaften

Formel
C9H18NO2
Molmasse
172.25
Schmelzpunkt
69-72°
Flammpunkt
146°(295°F)
Löslichkeit
Soluble in water, ethanol, methanol and dimethyl sulfoxide.

Anwendungen

Superoxide scavenger with neuroprotective, anti-inflammatory and analgesic effects4-Hydroxy-TEMPO free radical is used as a catalyst and a chemical oxidant by virtue of being a stable radical. It is used for detoxifying reactive oxygen species in medicinal chemistry. It is involved in the catalysis of disproportionation of superoxide and facilitates hydrogen peroxide metabolism. It is used to prepare tris(2,2,6,6-tetramethyl-1-oxyl-4-piperidyloxy)trimellitate by reacting with benzene-1,2,4-tricarbonyl trichloride. Further, it is used as a free radical scavenger and exhibits neuroprotective, anti-inflammatory and analgesic effects. In addition to this, it has good inhibition effect to acrylic acid esters, methyl acrylate, acrylic acid, acrylonitrile, styrene and butadiene.

Bemerkungen

Store in a cool place. Incompatible with strong oxidizing agents.

Literaturverweise

Reviews: Synthesis and reactions of stable nitroxyl radicals: Synthesis, 190, 401 (1971); Advances in the chemistry of nitroxide spin labels: Chem. Rev., 78, 37 (1978); Recent advances in the chemistry of nitroxides and their applications in spin labelling: J. Sci. Ind. Res., 54, 623 (1995). For a brief feature on derived oxoammonium salts, see: Synlett, 1757 (2003).

Compare also 4-Acetamido-TEMPO, B23456 and TEMPO, A12733.

Recommended as a stabilizer (antioxidant) for the protection of unsaturated fatty acids and their derivatives: J. Am. Chem. Soc., 101, 6748 (1979).

żamoj?, K.; Wiczk, W.; Zaborowski, B.; Jacewicz, D.; Chmurzyński, L. Analysis of Fluorescence Quenching of Coumarin Derivatives by 4-Hydroxy-TEMPO in Aqueous Solution. J. Fluoresc. 2014, 24 (3), 713-718.

żamoj?, K.; Zdrowowicz, M.; Wiczk, W.; Jacewicz, D.; Chmurzyński, L. Dihydroxycoumarins as highly selective fluorescent probes for the fast detection of 4-hydroxy-TEMPO in aqueous solution. RSC Adv. 2015, 5 (78), 63807-63812.

Sunkaria, A.; Sharma, D. R.; Wani, W. Y.; Gill, K. D. Attenuation of Dichlorvos-Induced Microglial Activation and Neuronal Apoptosis by 4-Hydroxy TEMPO. Mol. Neurobiol. 2014, 49 (1), 163-175.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H315-H318-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.

Sicherheitshinweise: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1422990
Harmonized Tariff Code
2933.39
TSCA
Yes
RTECS
TN8991000

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