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1,2-Dimethoxyethane is widely used as a solvent for electrolyte of lithium batteries, polysilicones, oligo- and polysaccharides. It plays an important role in Grignard reactions, Suzuki reactions and Stille couplings in organometallic chemistry and in pharmaceutical synthesis. It is a higher boiling point solvent and is used as an alternative to diethyl ether and tetrahydrofuran. It is used for the etching of synthetic polymers like polytetrafluoroethylene and other fluoropolymers with alkali metal dispersions.
Solvent for lithiations and metal hydride reductions.
Recommended solvent for the Schmidt reaction of ketones with hydrazoic acid, avoiding potential hazards reported with the more usual chlorinated solvents, particularly chloroform. The hydrazoic acid is generated in situ from NaN3 and methanesulfonic acid: Tetrahedron, 52, 1609 (1996)./n
Che, P.; Lu, F.; Si, X.; Xu, J. Catalytic etherification of hydroxyl compounds to methyl ethers with 1,2-dimethoxyethane. RSC Adv. 2015, 5 (31), 24139-24143.
Monreal, M. J.; Thomson, R. K.; Scott, B. L.; Kiplinger, J. L. Enhancing the synthetic efficacy of thorium tetrachloride bis(1,2-dimethoxyethane) with added 1,2-dimethoxyethane: Preparation of metallocene thorium dichlorides. Inorg. Chem. Commun. 2014, 46, 51-53.
Gefahrenhinweise (EU): H225-H332-H360
Highly flammable liquid and vapour. Harmful if inhaled. May damage fertility or the unborn child.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.