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5-Chloroisatin is a reagent used in the synthesis of Schiff bases through the reaction with 2-methyl-4-nitroaniline or 4-amino-4,5-dihydro-1H-1,2,3-triazole-5-one.
MR Islam.; M Mohsin. Synthesis of isatin, 5-chloroisatin and their Δ 2-1, 3, 4 oxadiazoline derivatives for comparative cytotoxicity study on brine shrimp. Bangladesh Journal of Pharmacology. 2007, 2 (1), 7-12.
O Bekircan.; H Bektas. Synthesis of Schiff and Mannich bases of isatin derivatives with 4-amino-4, 5-dihydro-1H-1, 2, 4-triazole-5-ones. Molecules. 2008, 13 (9), 2126-2135.