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N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone.
Powerful silylating agent for a wide range of functional groups: J. Chromat., 115, 591 (1975); 134, 387 (1977); Chromatographia, 9, 440 (1976). See Appendix 4.
Cabanelas, D. G.; Wright, L. P.; Paetz, C.; Onkokesung, N.; Gershenzon, J.; Concepción, M. R.; Phillips, M. A. The diversion of 2-C-methyl-d-erythritol-2, 4-cyclodiphosphate from the 2-C-methyl-d-erythritol 4-phosphate pathway to hemiterpene glycosides mediates stress responses in Arabidopsis thaliana. Plant J. 2015, 82 (1), 122-137.
Wong, A. S. Y.; Ho, E. N. M.; Wan, T. S. M.; Lam, K. K. H.; Stewart, B. D. Metabolic studies of oxyguno in horses. Anal. Chim. Acta 2015, 891, 190-202.
Gefahrenhinweise (EU): H226-H315-H319-H335
Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.