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N-(9-Fluorenylmethoxycarbonyloxy)succinimide is the most efficient reagent for the selective preparation of N-(9-fluorenylmethoxycarbonyl) derivatives of hydroxy-amino acids. Dipeptide formation is lower than with the chloroformate, Fmoc-Cl. It is also employed in the synthesis of glycopeptides.
Reagent for the preparation of Fmoc derivatives of amino acids, avoiding problems arising from mixed anhydride formation; preferred especially for the protection of hydroxy amino acids: Can. J. Chem., 60, 976 (1982); Biopolymers, 22, 2157 (1983); Synthesis, 671 (1978). For peptide reagents, see Appendix 6.
Bartolami, E.; Gilles, A.; Dumy, P.; Ulrich, S. Synthesis of alpha-PNA containing a functionalized triazine as nucleobase analogue. Tetrahedron Lett. 2015, 56 (18), 2319-2323.
Wang, N.; Seko, A.; Takeda, Y.; Ito, Y. Preparation of asparagine-linked monoglucosylated high-mannose-type oligosaccharide from egg yolk. Carbohydr. Res. 2015, 411, 37-41.
Gefahrenhinweise (EU): H302-H317
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