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It decreases racemization in peptide synthesis and inhibits formation of N-acylureas.
H. Michael Petrassi.; K. Barry Sharpless.; Jeffery W. Kelly. The Copper-Mediated Cross-Coupling of Phenylboronic Acids and N-Hydroxyphthalimide at Room Temperature:? Synthesis of Aryloxyamines. Org. Lett. 2001, 3 (1),139-142 .
Haoxi Ben.; Arthur J. Ragauskas. Pyrolysis of Kraft Lignin with Additives.Energy Fuels. 2011, 24 (10), 4662-4668 .
Reportedly superior to N-Hydroxysuccinimide, A10312 as a racemization suppressant in peptide synthesis: Chem. Pharm. Bull., 22, 1857 (1974); 26, 585 (1978). See Appendix 6.
Reagent for preparation of O-alkylhydroxylamines by O-alkylation and cleavage with hydrazine: Bull. Soc. Chim. Fr., 833 (1976). Compare N-Hydroxyphthalimide, A13862.
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.