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109-04-6 - 2-Bromopyridine, 99% - A13241 - Alfa Aesar

A13241 2-Bromopyridine, 99%

CAS-Nummer
109-04-6
Synonyme

Größe Preis ($) Menge Verfügbarkeit
25g 27,90
100g 72,36
250g 127,88
500g 227,20
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

2-Bromopyridine, 99%

MDL
MFCD00006219
EINECS
203-641-6

Chemische Eigenschaften

Formel
C5H4BrN
Molmasse
158.00
Siedepunkt
192-194°
Flammpunkt
97°(207°F)
Dichte
1.625
Brechungsindex
1.5720
Löslichkeit
Slightly miscible with water.

Anwendungen

2-Bromopyridine is used in the preparation of a variety of biologically active compounds like antimalarial agents. It is also used to prepare beta-adrenoceptor agonist.

Bemerkungen

Keep away from heat, sparks, and flame. Hygroscopic. Incompatible with strong oxidizing agents, strong acids and acid chlorides.

Literaturverweise

Bromopyridines can be converted to the Grignards by Mg exchange with i-PrMgCl: Tetrahdron Lett., 40, 4339 (1999).

Reaction with n-BuLi gives 2-lithio-pyridine. Subsequent reaction at low temperatures with PCl3 gives, as the major product, 2,2'-bipyridine, along with a low yield of the expected tris(2-pyridyl)phosphine. POCl3 or SOCl2 also promote the symmetrical coupling reaction: Heteroatom. Chem., 5, 409 (1994). In contrast, reaction with LDA in THF at -78o results in lithiation at the 3-position, giving access to 3-substituted 2-bromopyridines: Synthesis, 235, 237 (1982). See also: Org. Lett., 3, 835 (2001).

Kathiravan, S.; Ghosh, S.; Hogarth, G.; Nicholls, I. A. Copper catalysed amidation of aryl halides through chelation assistance. Chem. Commun. 2015, 51 (23), 4834-4837.

Liu, C.; Li, X.; Liu, C.; Wang, X.; Qiu, J. Palladium-catalyzed ligand-free and efficient Suzuki-Miyaura reaction of heteroaryl halides with MIDA boronates in water. RSC Adv. 2015, 5 (67), 54312-54315.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H310-H315-H319-H335

Toxic if swallowed. Fatal in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P280h-P305+P351+P338-P309-P310

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Weitere Referenzen

Beilstein
105789
Gefahrenklasse
6.1
Verpackungsgruppe
II
Harmonized Tariff Code
2933.39
TSCA
Yes
RTECS
US3850000

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