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It is used as pharmaceutical intermediate. It is a Grignard reagent (with CuBr in dioxane) can introduce pentafluorophenyl groups.
S.G. Frankiss.; D.J. Harrison. Thermodynamic properties of fluorine compoundsXVI. The vibrational spectra and thermodynamic functions of pentafluorobenzene, chloropentafluorobenzene, bromopentafluorobenzene and methylpentafluorobenzene. Spectrochimica Acta Part A: Molecular Spectroscopy. 1975, 31 (12),1839-1864 .
D.V. Fenby.; S. Ruenkrairergsa. Aromatic fluorocarbon mixtures I. Excess enthalpies of benzene + chloropentafluorobenzene, + bromopentafluorobenzene, and + iodopentafluorobenzene. The Journal of Chemical Thermodynamics. 1973, 5 (2),227-232 .
Reaction of the Grignard reagent with CuBr in dioxane leads to pentafluorophenylcopper, useful for introduction of the pentafluorophenyl group by reaction with a wide range of electrophiles, e.g. halogens, acyl halides, alkyl, aryl and vinyl iodides, etc. For tabulated results, see: Org. Synth. Coll., 6, 875 (1988).
Gefahrenhinweise (EU): H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.